In vitro activities of ofloxacin and four other new quinoline-carboxylic acids against Chlamydia trachomatis.
نویسندگان
چکیده
The in vitro activities of five new quinoline-carboxylic acids against 2 reference strains and 45 clinical isolates of Chlamydia trachomatis of genital origin were compared with the activities of minocycline and doxycycline. Ofloxacin was the third most active agent (after the two tetracyclines), followed by ciprofloxacin, NY-198, and AM-833.
منابع مشابه
Activities of new quinoline derivatives against genital pathogens.
The in vitro activities of four quinoline carboxylic acids against 48 strains of Neisseria gonorrhoeae, 10 of Chlamydia trachomatis, and 32 of Ureaplasma urealyticum were compared. Ciprofloxacin was the most active against N. gonorrhoeae and C. trachomatis but had poor bactericidal activity against U. urealyticum, whereas ofloxacin showed the most bactericidal activity against U. urealyticum bu...
متن کاملComparison of the in vitro activities of ofloxacin and tetracycline against Chlamydia trachomatis as assessed by indirect immunofluorescence.
The in vitro activity of ofloxacin (DL8280), a new pyridone carboxylic acid, against Chlamydia trachomatis serotype E was assessed by growth of chlamydia in cycloheximide-treated McCoy cells. Chlamydia-infected monolayers were exposed to the drug for 48 and 96 h and for 48 h followed by 48 h of further incubation after withdrawal of ofloxacin. Inclusions were visualized by indirect immunofluore...
متن کاملIn vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis.
Sparfloxacin was more potent than other quinolones (tosufloxacin, lomefloxacin, ciprofloxacin, ofloxacin, fleroxacin, enoxacin, and norfloxacin) and as potent as minocycline and doxycycline in activity against Chlamydia trachomatis in vitro and in vivo. Sparfloxacin was more bactericidal than minocycline against C. trachomatis D/UW-3/Cx.
متن کاملThe in-vitro activity of grepafloxacin against Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum and Legionella spp.
The activity of grepafloxacin, a new orally active fluoroquinolone, was compared with the activities of ofloxacin, clarithromycin and doxycycline against Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Mycoplasma hominis and Ureaplasma urealyticum, and with the activities of ofloxacin, clarithromycin and rifampicin against Legionella spp. Grepafloxacin (MIC range 0.06-0.12 m...
متن کاملIn-vitro activity of gatifloxacin against Chlamydia trachomatis and Chlamydia pneumoniae.
We compared the activity of gatifloxacin, a new quinolone, ofloxacin and erythromycin against five isolates of Chlamydia trachomatis and 20 isolates of Chlamydia pneumoniae, including TW183 and clinical isolates from the USA and Japan. Testing was done in cycloheximide-treated HEp-2 cells. Gatifloxacin was slightly less active against C. trachomatis and slightly more active against C. pneumonia...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 32 11 شماره
صفحات -
تاریخ انتشار 1988